Gemcitabine-induced Acute Lipodermatosclerosis-like Reaction

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Gemcitabine-induced acute lipodermatosclerosis-like reaction.

Gemcitabine is considered to be a well-tolerated and safe cytostatic drug because of the relative lack of side effects. Cutaneous reactions due to gemcitabine treatment, including alopecia and maculopapular eruption, are well known. We report one patient with squamous cell carcinoma of the lung who developed a gemcitabine-induced cutaneous reaction mimicking acute lipodermatosclerosis. This cas...

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Lipodermatosclerosis.

The most commonly recognized form of lipodermatosclerosis (LDS), chronic LDS presents with induration and hyperpigmentation of the skin involving the one or both of the lower legs in a characteristic "inverted champagne bottle" appearance. Associated with venous insufficiency, LDS is most common in middle aged women. In addition to chronic LDS, an acute form may also occur and is often misdiagn...

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Gemcitabine-induced acute coronary syndrome: a case report.

OBJECTIVES To report a case of metastatic leiomyosarcoma, in which a patient developed chest pain accompanied by acute left bundle-branch block (LBBB) after gemcitabine infusion. CLINICAL PRESENTATION AND INTERVENTION A 59-year-old woman admitted with bilateral pulmonary nodules had classic risk factors for coronary heart disease and coronary stenosis as demonstrated by previous coronary angi...

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Bupropion hydrochloride induced serum sickness-like reaction.

BACKGROUND Bupropion hydrochloride is used frequently in the treatment of depression and in smoking cessation therapy. METHODS We report a case of bupropion hydrochloride induced serum sickness-like reaction. RESULTS There was complete resolution of symptoms on discontinuing bupropion and instituting therapy with prednisone and antihistamines. CONCLUSION This case is seemingly the first r...

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Gemcitabine-induced pulmonary toxicity.

BACKGROUND Gemcitabine is the only approved cytotoxic agent for the treatment of pancreatic cancer by the Food and Drug Administration. In addition, gemcitabine is also commonly used for the management of breast, ovarian, and non-small cell lung cancer. Myelosuppression is the most common toxicity of gemcitabine therapy. Pulmonary toxicities due to gemcitabine have, however, been reported. Dysp...

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ژورنال

عنوان ژورنال: Acta Dermato-Venereologica

سال: 2001

ISSN: 0001-5555

DOI: 10.1080/000155501317208381